Evaluation of the effect of using probiotic products to control the symptoms of hospitalized patients with definite diagnosis of COVID-19
Phase 3 trial, Randomized trial, with block randomization on 60 covid-19 patients, in two groups control and intervention, follow for 14 days.
Settings and conduct
Firoozabadi hospital, after infectious disease specialist visit and definite diagnosis of covid19, with block randomization, divided two groups, intervention and control then prebiotic will take to intervention patient.
Participants/Inclusion and exclusion criteria
Inclusion criteria: definite Covid19 patients; individual satisfaction.
Exclusion criteria: pregnancy and breastfeeding; ICU admission; using herbal remedies; chemotherapy.
Intervention group: standard therapy plus prebiotic.
Control group: standard therapy.
Main outcome variables
Evaluation of Prebiotic on Covid19; fever; cough; respiratory rate; weakness; myalgia
Reason for update
IRCT registration information
IRCT registration number:IRCT20161206031255N4
Registration date:2020-12-07, 1399/09/17
Last update:2020-12-07, 1399/09/17
Name of organization / entity
Iran university of medical sciences
Iran (Islamic Republic of)
+98 912 320 4006
Expected recruitment start date
Expected recruitment end date
Actual recruitment start date
Actual recruitment end date
Trial completion date
Evaluation of probiotic use on control of sign and symptoms of admitted patients with covid-19
ٍEfficacy of prebiotic products on admitted patients with Covid-19
positive PCR or positive CT-scan
Patient's unwillingness to participate
ICU admitted or intubated patients
Pregnancy orbreast feeding
use of steroid or immunosupressive medicatns
use of the other herbal medications
No age limit
Groups that have been masked
Target sample size:
Randomization (investigator's opinion)
Initially, before starting the sampling, the row number from 1 to 60 is considered for all patients. Then, with the software SPSS, half of the numbers are randomly given to the patient group and the other half to the control. As soon as the patient enters the study, the row number is considered in the list in the order of entry. Grouping was done based on predetermined numbers.
Blinding (investigator's opinion)
Other design features
Name of ethics committee
Ethic's commitee of Beheshti university of Medical Sciences