Comparison of two methods of calculating the dose of propofol for induction of general anesthesia according to either Ideal Body Weight(IBW) or Fat Free Mass(FFM), in morbid obese patient: parallel double - blinded clinical trial

Selecting the appropriate drug dose calculation method to induce anesthesia with propofol based on IBW or FFM , which will ultimately prevent drug overdose and reduce drug side effects.

Clinical trial, randomized, double_ blinded, parallel group design of 40 patients.

40 patients with obesity and candidates for morbid obesity surgery are selected. Patients are divided into two groups based on the dose of propofol received to induce anesthesia. The patient is asked to hold a 20 cc syringe of normal saline. Propofol is injected in 15 seconds at a dose of 2 mg / kg based on the weight of the study group through a Cath-TEC with 10 cc of normal saline. Decreased alertness is determined by dropping the syringe. The patient is then asked to open his eyes and an eyelid test is performed. Indicators such as depth of anesthesia, heart rate and blood pressure are then measured. Finally, by comparing the results, we will reach the appropriate dose to induce anesthesia in patients with morbid obesity. This study is performed in Firoozgar Hospital

40 patients with obesity over body mass over 35, age 18-59 years, ASA two and three who are selected as candidates for morbid obesity surgery. Patients are divided into two groups based on the dose of propofol received to induce anesthesia, IBW or FFM. Patients with difficult airway, need for awake intubation, severe systemic disease, hepatic or renal impairment, drug allergies, behavioral disorders, or psychiatric medications were not included in the study.

First group: Patients by calculating weight based on FFM Second group: Patients by calculating weight based on IBW In both groups, propofol is injected in 15 seconds at a dose of 2 mg / kg based on the calculated weight.

Blood pressure, heart rate, decreased consciousness

In this study, we use the block randomization method so that after selecting patients according to the inclusion and exclusion criteria by selecting numbers from the table of random numbers and adapting to the blocks, patients are divided into study groups.To randomize the two treatment methods, we create 4 blocks in six different states, then select a number using the table of numbers, and determine the study groups by matching the numbers with the blocks. For example, if the first digit of our number is 1 to 6, select a block and the division is done, but if, for example, our number is 94071, the digit 9 is not valid and we select the next digit. Here, based on the block, we divide 4 people into groups. 1. TTCC 2. TCTC 3. TCCT 4. CCTT 5. CTCT 6. CTTC

The anesthesiologist who is going to administer the drug is aware of the study group, while data recording is performed by another person who is not aware of the administered dose. This is a randomized double-blind study in which the patient and the person who recording and evaluating the data is not aware of the dose of the drug administered.

There is no more information

Participants' personal data is shared after identifying individuals and the main outcome of the study.

Access period starts 6 months after the results are published

Only researchers working in academic and scientific institutions

Use the appropriate dose of medication to induce general anesthesia and prevent drug side effects

E-mail

Send email