A Study of the Effect of Intravenous Infusion of Magnesium Sulfate on the Level of Intraoperative End-Tidal CO2 and Postoperative Pain in Laparoscopic Cholecystectomy

A Study of the Effect of Intravenous Infusion of Magnesium Sulfate on the Level of Intraoperative End-Tidal CO2 and Postoperative Pain in Laparoscopic Cholecystectomy

This study is a Randomized Clinical Trial Study that will be performed in Rafsanjan. The study sample consisted of 62 patients with laparoscopic cholecystectomy. Patients are divided into two groups of 31 intervention and control using a random number table. The magnesium group received 50 mg/kg of Mg sulfate IV in 100 cc normal saline 0.9% and the control group 100 cc N.S 0.9%. CO2 will be recorded by the anesthesia resident before and after surgery, and the severity of postoperative pain during recovery, the second, sixth, 12th, and 24th hours will be measured using the Visual Analogue Scale (VAS). Data on patients' personal information are collected and recorded using a checklist. Also, the amount of changes in end-expiratory carbon dioxide, used opium dose and VAS index in the mentioned hours will be compared between the two groups and will be statistically analyzed by SPSS 21 software.

In this double-blind study, 62 patients of laparoscopic cholecystectomy will be presented in Ali Ibn Abitaleb Hospital of Rafsanjan.

62 patients with laparoscopic cholecystectomy with inclusion criteria including ASA classification I-II patients, 20 to 60 years of age and exclusion criteria including: drug hypersensitivity to magnesium sulfate, drug abuse, any neuromuscular disease, EF less than 40% and hypotension or bradycardia during anesthesia by more than 20%, cardiac disease, hepatic failure and kidney failure, chronic respiratory failure and morbid obesity.

Mg group receives 50 mg/kg of Mg sulfate IV in 100 cc of N.S 0.9% and control group 100 cc of N.S 0.9%.

End-Tidal CO2 Pain Severity

This study is performed by simple randomization method using Random Number Table tool and the randomization unit is individual. Random Number Table is a set of numbers that is generated without a specific pattern or order and in a completely random form and has become a table. To use the table of random numbers, the researcher first determines the table to read the numbers from top to bottom. The second assumption of the researcher is to consider numbers for different groups, in which even numbers are considered for the case group and odd numbers for the control group. The researcher then touches one of the numbers and moves in one of the predetermined directions and records the numbers and assigns them to two groups (case and control). Random allocation concealment method in this study is SNOSE method. In this method, first a random sequence is performed, then based on the size of the research sample, a number of envelopes with aluminum wrappers are prepared and each of the random sequences created is registered on a card and the cards are placed inside the envelope. In order to maintain a random sequence, envelopes are numbered in the same way on the outer surface of the envelopes. Finally, the lids of the envelopes are glued and placed in a box, respectively. At the beginning of the registration of participants, one of the envelopes of the letter is opened and the assigned group of the participant is revealed according to the order of entry of the eligible participants. In the implementation phase of the random allocation process of this study, cases such as the individual who created the random sequence, the person who examined the participants in terms of inclusion and exit criteria, and the participants who studied and participated in the study. Assigned, it is intended that on this basis, three separate individuals perform the randomization process without being aware of the actions of other researchers.

In this study, each participant is assigned a code that the data analyzer and the participant are unaware of which group the assigned code belongs to.