Men and women of at least 18 years of age capable of providing informed consent
Confirmation of COVID-19 with RT-PCR
Need for hospitalization
No need for mechanical ventilation
No need to more than 10 L/min of supplemental oxygen by any device.
The patient must meet at least one of the following high-risk criteria: age 70 years or older, obesity (BMI ≥ 30 kg/m2), diabetes mellitus, uncontrolled blood pressure (systolic blood pressure> 150 mm Hg), history of respiratory disease (Including asthma or COPD), history of heart failure, history of coronary artery disease, fever > 38.4°C in the last 48 hours, shortness of breath at the time of referral, Bicytopenia, Pancytopenia, or a combination of neutrophilia and lymphopenia
History of allergy to dimethyl fumarate
Use of dimethyl fumarate before current hospitalization
Patients more than 70 years of age with a history of any of the following in the last six months: Class III / IV Heart Failure Based on the New York Heart Association (NYHA) classification, Insulin-dependent diabetes, Angina pectoris, Malignancy
Uncontrolled bacterial, fungal, or viral infection (other than COVID-19).
Any history of receiving convalescent plasma therapy
Absolute neutrophil count (ANC) < 500
Platelets count < 50,000
Pregnant women or those intending to become pregnant
AST or ALT > 5 times the upper limits of normal (ULN)
Estimated glomerular filtration rate (eGFR) < 30 ml/min in 1.73 m2 using MDRD equation