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Study aim
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Determining the effects of ketogenic diet on weight management and apptite in overweight or obese individuals with weight regain and food addiction
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Design
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Clinical trial with control group, with parallel, randomized groups, on 50 obese or overweight adults. Excel software rand function was used for randomization.
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Settings and conduct
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Candidates are asked to attend the nutrition clinic of Shahid Beheshti University at the beginning and end of the project. After filling out the required consent and questionnaires, blood samples are taken, the physical composition of the volunteers is measured with an InBody device, stool samples are taken from the volunteers. And finally a proper diet is given to people.
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Participants/Inclusion and exclusion criteria
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Inclusion criteria: Healthy adults who are obese or overweight with weight regain with food addiction
Exclusion criteria: Gout and chronic diseases such as diabetes, cardiovascular, liver, etc. Neurological diseases (depression, bipolar disorder, and obsessive-compulsive disorder) Follow a special diet, use drugs that affect appetite and weight, and use any probiotic product in one recent month of antibiotic use in the last month.
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Intervention groups
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Obese or overweight adults with recurrent weight regain with food addiction
Ketogenic diet for intervention group
Dietary control group with calorie restriction
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Main outcome variables
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plasma serotonin level, plasma BDNF level, eating behavior, weight, body mass index, waist circumference, hip circumference, waist to hip ratio, fat mass percentage Body, percentage of lean body mass, weight of body fat mass, body weight of lean body mass, percentage of visceral body fat, amount of visceral body fat, appetite, Bacteroides abundance, Lactobacillus abundance, Bifidobacterium abundance, Megamonas abundance, Eubacterium abundance, Akkermansia abundance, Urine ketone