The effect of N-acetyl cysteine in Prime solution on reducing myocardial stress in coronary artery bypass surgery

Determining the effect of Nacetylcysteine ​​on reducing Stress to the myocardium in coronary artery bypass surgery

This study is a double-blind clinical trial. Patients are divided into intervention and control groups by a simple random method (by software). The sample size is 20 cases in each group. In the intervention group, N-acetylcysteine ​​(25mg/kg) was added to the prime solution, and in the control group, an equivalent volume of placebo (normal saline) was prescribed. SPSS software is used for data analysis.

Sampling is done from patients undergoing coronary artery bypass surgery in Shahid Chamran Hospital, Isfahan. Clinical staff, patients and data analyst in the study do not know the type of intervention for patients. Patients randomly participated in one of two groups, Nac and placebo The dose of the intervention group is added to the prime solution, N-acetylcysteine ​​(25mg/kg) and in the control group, an equivalent volume of placebo (normal saline) is administered.

Main conditions for entering the study: age 40-70 years, coronary artery transplant candidate, EF ≥ 50% Major exclusion conditions: EF less than 50, asthma, kidney failure, sensitivity to NAC

Patients are randomly divided into 2 intervention-control groups. In the intervention group, N-acetylcysteine ​​(25mg/kg) is added to the prime solution, and in the control group, an equivalent volume of placebo (normal saline) is prescribed.

Investigation of damage to the myocardium by measuring indicators: troponin I before operation, immediately after operation and 8 hours after operation / CRP before operation, immediately after operation and 24 hours after operation / need for shock and pacemaker

The randomization of patients between two groups is done by Selde random method and using random assignment software (RAS). In this software, the total number of sample size (40 people) and the number of groups (two groups) are entered into the software. The output of the software includes a list that randomly distributes the numbers 1 to 40 in two groups. Patients are entered into one of the two groups according to the time of visiting the hospital and according to the mentioned list, so that the sample size reaches the required number in each group.

In this study, the participants, clinical caregivers (laboratory, operating room personnel, nurses), those who evaluate the outcome and those who analyze the data are unaware of the type of drug received and these people do not know which the participant is in. The group (intervention/control) is located.