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Study aim
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Determining the effect of two different doses of 1 and 0.75 (µg/kg) dexmedetomidine on the control of heart rate and blood pressure during the use of tourniquet in upper extremity surgery
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Design
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Clinical trial with control group, parallel groups, triple-blind, randomized, phase 3 on 90 patients
Randomization with random allocation software
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Settings and conduct
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In Kashani hospital in Isfahan, under EKG monitoring, non-invasive blood pressure and pulse oximetry Dex group 1, 1 (µg/kg) dexmedetomidine induced within 10 minutes, continuation with 0.75 (µg/kg) Dex group 2, 1 (µg/kg) dexmedetomidine induced within 10 minutes, continuation with 1 (µg/kg) Saline group (control), normal saline infusion Identical syringes are used Induction of anesthesia using sodium thiopental 5 (mg/kg), fentanyl 3 (µg/kg), atracurium 0.6 (mg/kg) Maintenance of anesthesia using propofol 0.75 (min/µg/kg) and remifentanil 0.1 (min/µg/kg) Measurement and recording of systolic, diastolic, and mean arterial blood pressure, heart rate, and SpO2 at baseline and at 0, 10, 20, 30, 40, 50, and 60 minutes after inflating the tourniquet and right after emptying it The patient, the person who collects the data, and the statistician are blinded.
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Participants/Inclusion and exclusion criteria
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Inclusion criteria: patients with ASA (American Society of Anesthesiologists) = 1, aged 18-65 years
Exclusion criteria: drug addicts, people with a history of allergy to studied drugs, people with heart, liver and kidney failure, allergy to study drugs, change in anesthesia method, duration of tourniquet less than 60 or more than 150 minutes
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Intervention groups
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Three groups of 30 patients, dexmedetomidine 1 and 2 and the control group Dex group 1: dose 0.75 (µg/kg) of dexmedetomidine infusion Dex group 2: dose 1 (µg/kg) of dexmedetomidine infusion Control group: normal saline infusion
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Main outcome variables
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Heart rate; Blood pressure