Evaluation of the Effect of Topical Herbal Product Based on Olive Oil and Dietary Recommendations Based on Persian Medical Resources in Patients with Resistant Head Lice Treatment

Determining the effect of a topical herbal product based on olive oil containing essential oils of two plants myrtle and oregano and combining it with dietary recommendations in patients with treatment-resistant head lice.

A controlled, parallel-group, single-blind, randomized, phase 3 clinical trial on 90 patients. The randomization process was done using the online computerized random allocation sequence and through the dedicated website (https://www.sealedenvelope.com/) of the randomization process.

The required sample size for each group will be 30 people. After selecting girls' primary schools with a simple random method, students with pediculosis resistant to disease treatment are included in the study. The patients are divided into three groups, the control group is treated with 4% dimethicone lotion twice with an interval of seven days, and the first intervention group takes the medicine three times with an interval of seven days, and the third group receives the medicine and dietary recommendations.

Female children with head lice who have not improved with two consecutive courses of treatment; insensitivity to plant essential oils; age 6 to 12 years old; no history of asthma, allergies and skin allergies according to the parents' report; absence of chronic skin disease.

Patients are randomly divided into three groups: the control group receives 4% dimethicone lotion twice with an interval of seven days, the first intervention group receives a topical herbal product three times with an interval of seven days, and the third group receives medication and dietary recommendations. .

1-The rate of complete recovery based on examination 2-Assessing the severity of pruritus 3-Evaluation of dryness, redness, scaling and irritation to the extent of complications

Eligible people are randomly assigned to the groups under study (the herbal product consuming group, the herbal product consuming group with dietary recommendations, and the control group) in a simple random manner and in a ratio of 1:1:1. The randomization process will be done using the online computerized random allocation sequence and through the dedicated website of the randomization process. Allocation of individuals/patients (Randomization) to the groups under study will be hidden for the patient, physician/interventionist, and outcome assessor (allocation concealment). In this way, the belonging of the people to the groups under study is marked on the paper/card and placed inside the opaque envelopes so that its contents cannot be seen from the outside. During the visit of the eligible patient for the study, the attending physician takes one of the envelopes and then opens it, and based on the contents of the envelope, the patient is placed in the intervention 1, intervention 2 or comparison/control group and treatment services are provided.

Evaluators and analysts will be unaware of the intervention and control groups