Comparison of the efficacy of Alexandrite laser therapy versus medical therapy for the treatment of infraorbital dark circles in patients of dermatology clinic

Comparison of the Efficacy of Pharmacological Therapy and Alex Laser Therapy in Treating Dark Circles Under the Eyes in Patients Complaining of Dark Circles at a Dermatology Clinic in Tehran in 2024.

This clinical trial consists of two comparative groups undergoing treatment with laser therapy and topical medication, featuring parallel groups and a single-blind design. The allocation of participants to the groups was performed non-randomly. This is a Phase 2 study involving a total of 102 patients.

This clinical trial will involve 102 patients with periorbital hyperpigmentation, divided into two groups of 51. Participants will be unaware of each other's conditions. One group will receive four sessions of Alexandrite laser therapy at one-month intervals, while the other group will apply a modified Kligman formula nightly for six months, consisting of 0.1% betamethasone, 5% hydroquinone, and 0.05% tretinoin. The degree of hyperpigmentation will be assessed before and after treatment. Additionally, patient satisfaction with both treatment modalities will be evaluated and compared.

In general, patients presenting with complaints of dark circles under the eyes at the dermatology clinic who consent to participate in the study will be included. Those who express unwillingness to continue their participation or experience a severe medical adverse event will be withdrawn from the study.

In this study, two types of interventions will be conducted in two distinct groups for the treatment of infraorbital hyperpigmentation. One group will undergo treatment with Alexandrite laser for a total of four sessions in the under-eye area, while the other group will utilize topical medications nightly for a duration of six months.

Efficacy comparison of methods for infraorbital hyperpigmentation

In this study, a single-blind method has been used. In this approach, participants are unaware of the group allocation. This design was intentionally implemented to prevent any potential bias or psychological influence in the assessment of outcomes.

The individual data of participants in this study will be shared only after ensuring that the identities of individuals are rendered unidentifiable, thereby preserving the privacy of all participants.

The dissemination of these documents/data files will occur upon the complete conclusion of the research project. In the event that the project is published as a manuscript, access to the data will be granted following the completion of the publication process, and will remain available for a period of up to two years after the article's publication.

Due to the practical relevance of the project's subject matter in the fields of medicine, industry, and aesthetics, access will be granted to individuals who submit requests and are approved and deemed qualified by the project team.

Any utilization of the data from this study must be coordinated with the project team responsible for its execution and accompanied by a written permission statement from the research team to ensure the preservation of publication rights.

Applicants may contact us via email at the following address (or at a subsequently provided address in the event of any changes): s2000.edu.khoram@gmail.com.

Initially, you are required to introduce yourself and your research group in your email. Following this, please provide a comprehensive description of how the data will be utilized and the specific methodologies involved. It is essential to clearly and explicitly articulate the objectives of using the data. Subsequently, necessary arrangements will be coordinated with you by the project team.