Evaluation of the Effect of Hydroalcoholic Extract of Mespilus germanica L. Fruit on the Control of Alveolar Socket Bleeding after Mandibular Molars Extraction

Determining the average control time of alveolar Socket bleeding after using gauze impregnated with 20% and 40% extract of Mespilus germanica L. and gauze impregnated with normal saline.

Clinical trial with first intervention group (20% extract), second intervention group (40% extract), and control group (normal saline) with parallel groups, Three blind strains, Randomized, Phase 3 trial on 90 patients, Random allocation2 software was used for randomization.

In the department of surgery of Mazandaran university of medical sciences, sterilized gauzes in wet thermal autoclave with 4 cc extracts of 40 % and 20 % and normal saline are impregnated and then dried the gauzes in oven. the tooth is extracted by simple extraction method. The gauze is put into the patient's mouth with mild contact and soaked with normal saline. Every 5 minutes the gauze is removed from the patient's mouth and the bleeding or discontinuation is recorded. Due to the color matching of the solutions, the evaluator, patient, and statistical consultant participate in blinding.

Inclusion criteria: Mandibular Molars Extraction and Age ≥ 18 years, Insensitivity to the extract, Patients with ASA I and II, No smoking and hookah, Amenorrhea during surgery, Not using contraceptives, Not having a clotting disorder, Absence of uncontrolled infection at the surgical site Exclusion criteria: The presence of a large periapical lesion, the complications during surgery such as flap rupture, Patients with moderate and severe periodontal disease

Gauze impregnated with 20% extract of Mespilus germanica L. (A - treatment group) Gauze impregnated with 40% extract of Mespilus germanica L. (B - treatment group) Gauze impregnated with normal saline (C - control group)

Bleeding rate (clot formation) Bleeding control time

People who met the entry criteria were placed in two treatment groups and one control group. sterile gauzes soaked with extract of 20 % and 40 % Mespilus germanica L. were used for treatment group and sterile gauzes soaked with normal saline were used for control group. random block method will be used to allocate samples to three groups. For this purpose, patients will receive the number 1 to 90 according to the selection order. The randomization unit will be individually and by number with blocks of three people. The selection of the group type for each person will be done through random allocation2 statistical software. In order to construct a random sequence, codes A, B and C will be generated from the software, where code A means applying the the first intervention group (20% extract) and code B means applying the second intervention group (40% extract) and Code C means applying the control group to each person. Finally, the codes will be placed in the sealed envelope and the number of each patient will be written on the envelope. As each patient enters, the doctor will open the envelope and apply the desired treatment.

Due to the homogenization of the color of the normal saline solution and the extracts with each other, the evaluator, the patient and the statistical consultant are involved in blinding.