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Study aim
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The aim of the study is to evaluate and compare the effectiveness of curcumin gel and naproxen gel in the treatment of cervical myofascial pain syndrome (CMPS).
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Design
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Pragmatic, community based, parallel group, double blinded, randomized controlled trial. Total 105 patients will be enrolled. Patients who met our inclusion criteria will be randomized into two groups.
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Settings and conduct
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Muhammad Rehabilitation Centre, Multan
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Participants/Inclusion and exclusion criteria
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Inclusion Criteria: All ages diagnosed with cervical myofascial pain syndrome
Moderate to severe pain, No contraindications to curcumin or naproxen.Exclusion Criteria:
Pregnancy, lactation, severe cervical spine pathology, history of drug allergy, and prior treatment with corticosteroids or other anti-inflammatory medications within four weeks.
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Intervention groups
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Intervention Protocol: Group A: The respective gel (curcumin ) will be applied topically over the affected area at a dose of 2 grams., A therapeutic ultrasound device operating at 1 MHz frequency and 1.5 W/cm² intensity was used.Ultrasound will be applied for 10 minutes in a circular motion over the gel to enhance transdermal drug delivery.Treatments will be administered once daily for four weeks.
Group B: The respective gel (naproxen) will be applied topically over the affected area at a dose of 2 grams., A therapeutic ultrasound device operating at 1 MHz frequency and 1.5 W/cm² intensity was used.Ultrasound will be applied for 10 minutes in a circular motion over the gel to enhance transdermal drug delivery.Treatments will be administered once daily for four weeks.
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Main outcome variables
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Pain (NPRS), Cervical ROM (goniometry), Muscle tenderness (Pressure pain threshold scale), Quality of life (SF-36), Functional Status ( McGill Questionnaire), ESR, CRP, IL-6