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Study aim
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The primary aim of this study is to compare the effects of lipid-lowering drugs and a 10-week resistance band training program on lipid profiles, body composition, and overall health outcomes in obese patients with elevated cholesterol levels.
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Design
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Pragmatic, community based, parallel group, double blinded, randomized controlled trial. Total 380 patients will be enrolled.
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Settings and conduct
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Muhammad physical therapy clinic and rehabilitation center, Multan.
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Participants/Inclusion and exclusion criteria
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Inclusion criteria
• Adults aged 18-65 years
• Diagnosed with dyslipidemia, defined as elevated levels of total cholesterol, LDL cholesterol or triglycerides , or low HDL cholesterol
• Able and willing to adhere to either drug therapy or a structured exercise program
Exclusion Criteria
• History of cardiovascular diseases
• Uncontrolled hypertension
• Recent history of smoking or current tobacco use
• Conditions contraindicating exercise
• Current use of lipid-lowering drugs or recent participation in a structured exercise program
• Pregnant or lactating women
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Intervention groups
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Group A: Will receive e.g., Rosuvastatin 5mg administered orally once daily.
Group B: Participants in the exercise intervention group will undergo a structured resistance training program, tailored to individual fitness levels and conducted under the supervision of a certified exercise trainer. The exercise regimen will include a 5-minute warm-up, 30 minutes of resistance training (including chest press, seated row, shoulder press, biceps curl, squats, deadlift, wood chopper, Russian twists), followed by a 5-minute cool-down. Training sessions will be held three times a week for 12 weeks
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Main outcome variables
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Lipid profile parameters (total cholesterol, low density lipids, high density lipids, and triglycerides) will be measured at three time points: baseline, 5 weeks, and 10 weeks.