A comparative study of the effect of nasal dexmedetomidine and oral chloral hydrate on sedation of children during MRI

Comparison of the effects of nasal dexmedetomidine and oral chloral hydrate on sedation in children during MRI

Using the randomized block method, individuals are divided into two groups of 70 people and then the treatment is performed on them by the clinical caregiver. The study is an unblinded clinical trial, which is conducted as a four-way permutation block method in the rand function of Excel software.

Using a randomized block design, subjects were divided into two groups. The study was an unblinded clinical trial conducted at Al-Zahra Hospital using the rand function of Excel software for randomization.

Inclusion criteria: Children who are candidates for MRI who require sedation for any reason and whose parents have consented to participate in the study. Exclusion criteria: Patients with a history of respiratory disease, gastric ulcer or liver disease, treatment with drugs that interact with chloral hydrate or dexmedetomidine, the presence of a specific underlying disease that affects the interpretation of objectives such as sedation duration, any previous allergic reaction to chloral hydrate or dexmedetomidine.

first group: Children in this group will receive 5% chloral hydrate syrup at a dose of 50-100 micrograms/kg orally 10 minutes before the operation. In addition, for chloral hydrate, an initial dose of 50 micrograms/kg is given. If sedation is not sufficient, the dose will be 100 micrograms/kg. In the second group: Children in this group will receive intranasal dexmedetomidine at a dose of 2-3micrograms/kg 10minutes before the operation. The prescribed dose will start with a dose of 2micrograms/kg and if sedation is not sufficient, one microgram/kg will be added.

Sedation

With the convenience sampling method, the referring individuals who are eligible for the study are randomly divided into two groups: case and control. In this study, the division of individuals is done using the four-way permutation block method. In this method, A represents the individual who receives the intervention and B represents the individual who is in the control group. Considering the four-way block, we give the AABB permutation code 0, the ABAB permutation code 1, ABBA code 2, BAAB code 3, BBAA code 4, and BABA codes 5 to 9. Then, using the random number table, we randomly select a starting point and then consider the numbers in rows or columns. Considering the order of the numbers in the table, we assign the corresponding permutation to each number we encounter. Finally, 70 people will be divided into two groups.