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Study aim
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Comparison of time to first rescue analgesic inpatients receiving STAP block with ropivacaine and calcitonin and patients receiving ropivacaine alone.
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Design
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A clinical trial with 2 groups, with parallel groups, triple-blinded, randomized, phase 3 on 36 patients. For randomization, simple randomization is used using a random number table.
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Settings and conduct
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The STAP block is performed under ultrasound guidance and using a linear probe. After determining the layer of abdominal wall muscles (external oblique, internal oblique, and transverse abdominis), the needle is inserted into the space between the internal oblique muscle and the transverse abdominis muscle and the drug solution is injected.
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Participants/Inclusion and exclusion criteria
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Mental health, adequate understanding and awareness of the patient and providing informed consent for all laparoscopic cholecystectomy surgeries
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Intervention groups
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RC Group (Ropivacaine with Calcitonin): -
Bilateral Subcoastal TAP Block with 20 mL Ropivacaine 0.2% Solution + 50 Calcitonin Units on Each Side
Group R (Ropivacaine only):
- Bilateral subcostal TAP block with 0.2% ropivacaine with a volume of 20 mL for each side (containing normal saline as a placebo instead of calcitonin)
Postoperative data: Time to first rescue palliative, VAS pain scores will be measured at 0, 2, 4, 6, 12, and 24 hours, total opioid intake, and incidence of adverse events (e.g., nausea, vomiting, itching)
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Main outcome variables
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Time to the first rescue analgesic