-
Study aim
-
Determine the effect of combined low-carbohydrate diet with time-limited feeding method on anthropometric indicators, liver parameters, metabolic factors and Inflammation in patients with non-alcoholic fatty liver disease
-
Design
-
A clinical trial with a control group, with parallel groups, without blinding and randomized with a sample of 50 people. A table of random numbers was used for randomization.
-
Settings and conduct
-
NAFLD Patients referred to Tehran's GI clinics with the desired criteria and personal satisfaction were selected and fibroscanned, and in case of steatosis grade 2 or higher based on CAP score>263, after 12-14 hours of fasting, 5 cc of blood is taken for biochemical evaluation. At the beginning and the end, weight, height, BMI, general profile and physical activity questionnaire are completed and the 24-hour-food recall is filled for three days at the beginning, week 6 and 12. 24-hour food recall analysis is done with Nutritionist-IV and all patients are given dietary-physical activity advice. For 12 weeks, the intervention group was prescribed a LCD+TRF, but control group only received dietary recommendations. At the end, fibroscan and blood test are repeated and weight and BMI are recalculated.
-
Participants/Inclusion and exclusion criteria
-
Non-alcoholic fatty-liver patients
-
Intervention groups
-
The intervention group is prescribed a low-carbohydrate-diet and time-limited-feeding for 12 weeks and patients in the control group only receive dietary recommendations.
-
Main outcome variables
-
Determining and comparing weight, BMI,waist and hip circumference, physical activity, total energy, protein, carbohydrate, fiber, total-fat, SFA, MUFA, PUFA, cholesterol, vitamin-E, vitamin-C, zinc, selenium in the diet, ALT, AST, degree of steatosis and liver fibrosis, glucose homeostasis indices, lipid profile and hs-CRP at the beginning and end of the two groups and in each group.