Comparison of the Pain Degree of Patients Receiving Analgesia with Abdominal Nerve Block in Patients Undergoing Laparoscopic Cholecystectomy: A Clinical Trial Study

Comparison of the Pain Degree of Patients Receiving Analgesia with Abdominal Nerve Block in Patients Undergoing Laparoscopic Cholecystectomy

The clinical trial is a controlled, parallel-group, double-blind, randomized, phase 3 trial on 50 patients, using block randomization.

Our study population is patients undergoing laparoscopic cholecystectomy surgery at the Imam Reza Hospital (AS) Educational and Medical Center in Birjand in 1403. The patients will be randomly divided into two groups as follows: A) The patient received the narcotic pethidine at a dose of 25 mg intravenously. B) Transverse abdominal nerve block (TAP) using 20 ml of 0.25% Ropivacaine Any complications such as nausea, vomiting, dizziness, respiratory depression, ataxia, dry mouth, tremor, diplopia, itching, paresthesia, allergic reaction, and hemodynamic disturbances and arrhythmias are recorded. In case of a score of 4 to 6, ketorolac is administered at a dose of 30 mg intravenously at most every six hours, and for a pain score of 7 to 10, 50 mg pethidine or 5 mg morphine is administered subcutaneously.

Patients between 18 and 65 years of age, who are in ASA class I and II and underwent laparoscopic cholecystectomy. Informed consent is required to participate in the study. Exclusion criteria also include sensitivity to the drugs used, use of narcotics, use of anticoagulants, previous history of upper gastrointestinal bleeding, severe renal or hepatic disease, or psychiatric disorders.

A) The patient received the narcotic pethidine at a dose of 25 mg intravenously. B) Transverse abdominal nerve block (TAP) using 20 ml of 0.25% Ropivacaine

Pain Severity, Cumulative Analgesic Dose

For randomization, first we create blocks of four including BABA, BAAB, ABBA, ABAB and write them on a piece of paper and put them in a sealed envelope. Then one of these envelopes is selected and the patient is placed by the anesthesiologist (who is not involved in the data collection and analysis) and the next three patients are determined on this basis and the desired intervention is performed in the recovery room by the anesthesiologist. For the other patients, their placement in different groups is done on the same basis.

This study is double-blind study, so that the subject and the evaluator are unaware of the allocation status. In this way, the subject is unaware of the contents of the syringes, which are identical in shape and quantity. The evaluator also measures clinical and diagnostic measurements using coding that is unknown to him/her.

All data is potentially shareable after de-identifying individuals.

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