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Study aim
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To determine the effects of twelve weeks of multicomponent training and eight weeks of follow-up after the intervention on inflammatory and cardiometabolic markers, physical performance, and body composition in patients with multiple sclerosis.
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Design
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A controlled clinical trial with intervention and control groups, without blinding, randomized, on 50 patients.
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Settings and conduct
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Patients with MS referred to the Isfahan MS Center will be enrolled in the study if they meet the entry criteria and will be randomly assigned to two intervention and control groups. No blinding will be performed. The training sessions will be held in a gym at the University of Isfahan.
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Participants/Inclusion and exclusion criteria
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Inclusion criteria: Ability to walk, sit, and stand, Expanded disability status scale (EDSS) between 2 - 4, confirmation of MS by a neurologist;
Exclusion criteria: Participation in regular exercise for 6 months prior to the study, pregnancy for women, smoking
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Intervention groups
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The intervention group will participate in 12 weeks of multi-component training in the form of 3 training sessions per week, each session including endurance, strength, and balance exercises for 40 minutes. The control group will not have any training during the 12 weeks.
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Main outcome variables
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Tumor necrosis factor alpha; C-reactive protein; Interleukin-6; Adiponectin; Leptin; Cardiometabolic index; Triglyceride; High-density lipoprotein cholesterol; Low-density lipoprotein cholesterol; Total cholesterol; Glucose; Glycosylated hemoglobin (HbA1c); Insulin; Insulin resistance; Blood pressure; Peak oxygen consumption; Aerobic endurance; Mobility; Strength; Walking speed; Balance; Fatigue; Body mass index; Percent Body Fat.