A comparative study of the efficacy of piroxicam ampoule mesotherapy injection and shockwave modality on the clinical manifestations of knee osteoarthritis patients

Comparison of effectiveness of piroxicam ampoule mesotherapy injection and shockwave modality on clinical manifestations and performance in patients with knee arthritis

The clinical trial has a control group, with parallel groups, a blind strain, randomized, phase two on 60 patients, the method of random assignment in This study is the permutation block method of 4

Project location: Imam Reza Physical Medicine and Rehabilitation Clinic the patients are divided into two groups, the first group is the mesotherapy injection of piroxicam ampoule in certain points of the knee and the second group is the shockwave modality in the painful points around the knee. Blinding is also done in a one-way blind way where the clinical supervisor does not know the type of study

Inclusion criteria: mild and moderate osteoarthritis of the knee exclusion criteria: history of knee injection and knee injury, any kind of surgery on the knee. Various diseases including diabetes and...

The first group: patients received a subcutaneous injection containing a Combination of piroxicam and lidocaine 2%, at the acupuncture points ST34, ST35, SP9, BL 38, SP10, LR7 around the knee. After 10 days, the injection will Be done again (each patient will receive two mesotherapy sessions). The second group treated with shockwave modality, patients will receive 0.05 MJ/mm2 of total energy with 1000 pulses per week for 3 weeks.

Patient performance ,dependent ,somewhat continuous Pain level ,dependent ,somewhat discrete

The random allocation method in this study will be the permuted block randomization with blocks of size four. In this method, "A" represents the individual receiving the intervention, and "B" represents the individual receiving the control. Considering blocks of four, the total number of possible permutations is six, which are: ABAB, BABA, AABB, BBAA, ABBA, and BAAB. Then, using a table of random numbers and assigning codes from 0 to 9 to each permutation, a random list of 60 assignments is generated. This list includes 25 blocks of four (4 × 25 = 60, which corresponds to the total sample size). The order of assigning each method to the study participants is then determined accordingly. For example, the permutations are assigned codes as follows: ABAB = 0, BABA = 1, AABB = 2, BBAA = 3, BAAB = 4, and ABBA = 5 to 9. Then, using a table of random numbers, a random starting point is selected, and 25 numbers are randomly chosen (either row-wise or column-wise). The permutation corresponding to each selected number is recorded. (The order of the permutations will be arranged from left to right.) This process determines the allocation of all 60 participants into the two groups, A and B.

The study is one sided blind Clinical caregiver: to the person who is in charge of the care and follow-up of patients how to complete the questionnaires ,this person has no knowledge of the type of patients intervention .

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