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Study aim
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Determining the effect of lidocaine and dexamethasone intravenous injection on extubation time and postoperative complications in elderly patients undergoing vitrectomy.
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Design
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This study is a phase III, double-blind, randomized, parallel-group, control clinical trial that will be conducted on 60 patients aged 60 to 80 years, candidates for vitrectomy surgery under general anesthesia. Patients will be assigned to study groups using Random Allocation Software.
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Settings and conduct
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This study will be conducted at Feyz Hospital, Isfahan, on patients aged 60 to 80 years who are candidates for vitrectomy surgery under general anesthesia. In this double-blind study, participants, clinical caregivers, researchers, and the data collector will be blinded to the type of intervention. The study drugs (dexamethasone and lidocaine) will be prepared and injected in 2 cc syringes of identical appearance and volume by a nurse who is not involved in the data collection process.
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Participants/Inclusion and exclusion criteria
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Inclusion criteria: Patients aged 60 to 80 years with ASA I-II, candidates for eye surgery under general anesthesia who consent to participate in the study. Exclusion criteria: Movement disorders; history of postoperative nausea and vomiting; receiving antiemetics, corticosteroids, or analgesics in the last 24 hours; sensitivity to study drugs; inability to communicate.
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Intervention groups
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In this study, patients were divided into two intervention groups (receiving intravenous dexamethasone at a dose of 0.1 mg/kg) and control group (receiving intravenous lidocaine at a dose of 1.5 mg/kg).
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Main outcome variables
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Extubation time; severity of cough and sore throat; hoarseness; occurrence of nausea and vomiting; severity of pain and shivering after surgery; occurrence of laryngospasm; average length of stay in recovery;