Studying the effect of intraoperative dexmedetomidine infusion on acute renal failure in diabetic patients undergoing CABG surgery

Studying the effect of dexmedetomidine in reducing the incidence of AKI in diabetic patients receiving oral therapy during CABG surgery, On-Pump beating Study of changes in urea, creatinine, cardiac output, and GFR before, during, and after CABG surgery in the study groups. postoperative discharge rate, and duration of ventilatory support in the intensive care unit.

Clinical trial with two groups of Dex and placebo by double blindness on 90 patients (Placebo 45 and Dex 45)

In Qaim Hospital in Mashhad, 60 diabetic patients are receiving Dex or placebo infusion from the time of admission until they are transferred to the ICU.

35 <age<70 years, EF > 35%, diabetes treated with medication, candidate for elective CABG On-Pump beating with two or more grafts, provided that one of the grafts is the LIMA, HR> 65 on admission, GFR>50, ASA class II, hematocrit > 30% No concomitant heart valve surgery, underlying diseases Exclusion criteria: Reoperations and non-coronary, CABG Off-Pump, patient sensitivity to dexmedetomidine family of drugs, return to operating room from ICU, history of previous cardiac surgery, history of fever, trauma, bilateral carotid artery stenosis > 50%, difficult or prolonged intubation > 20 seconds, body mass index > 30, HR < 65/min, LM > 50%, history of bundle branch block, history of treatment with clonidine or methyldopa, presence of IABP

Dexmedetomidine infusion is started with an infusion pump in the dex group (dex diluted in saline at a concentration of 0.5 μg/kg/h) and in the placebo group, normal saline is started with an infusion pump at the same rate and continues until the end of the surgery.

Incidence of AKI in the first 48 hours after surgery in the ICU Creatinine and urea changes daily (on admission and 24 hours later) in the open heart ICU

Despite of giving informed consent, participants are unaware of whether they are receiving the drug or placebo. Similarly, the outcome assessor only sees and notes the outcomes and he is unaware of whether the patient received the drug or placebo.

I have not y decided et, but if the data is requested by email to the corresponding author, the data will be made available to other researchers. The report of the end of the study project will be registered in the Mashhad University of Medical Sciences' researcher system; the resulting article will be published in reputable journals.

If data is requested by email to the corresponding author, the data will be made available to other researchers within one week.

Responsible author

If the applicant has an approved proposal from one of the medical universities, the data will be made available to the researcher.

Responsible author

If data is requested by email to the corresponding author, the data will be made available to other researchers.