A comparison of the effects of 10 weeks of balance and aerobic exercises on the balance, cancer-related fatigue, and quality of life of children with leukemia.

The overall goal of the present study is to compare the effect of 10 weeks of balance and aerobic exercises on the balance, cancer-related fatigue, and quality of life in children with leukemia.

The study groups include the aerobic intervention group, the balance intervention group, and the control group. It has a control group, with factorial groups, non-blinded, randomized; the tests are conducted on-site/in the field on 27 patients.

The research is conducted at Bu-Ali Hospital in Sari, and the pre-tests include assessment of balance, fatigue (CFS-24h), and quality of life (PedsQL).

Inclusion Criteria: 1. Children with leukemia between the ages of 5 and 15 years. 2. Children in the maintenance phase of treatment with more than 20 weeks elapsed since the start of the phase. 3. Height, weight, and BMI within the normal range. 4. Children must be capable of performing physical activity. 5. Must not have symptoms related to acute illness, for example, fever (< 38 degrees Celsius), severe anemia. Exclusion Criteria: Non-leukemic individuals are excluded from entry."

Sample: 27 children with leukemia undergoing chemotherapy were randomly divided into three groups (9 children in each group). Balance Exercise Group: Static and dynamic exercises including two-leg standing, tandem stance, single-leg stance, and crossover walking; for 10 weeks, 2 sessions per week, with each session including a warm-up and cool-down. Aerobic Exercise Group: Outdoor walking for 10 weeks, 2 sessions per week; exercise intensity will be controlled based on the Karvonen formula (50% to 75% HRR) and the Visual Analog Scale (RPE=11-13). Control Group: No exercise intervention, maintaining usual lifestyle and receiving current medical care.

Aerobic fitness and balance improvement.

Randomization method: Simple. Unit of randomization: Individual. Stratified randomization. Randomization tool based on statistical software. Method of generating the random sequence: The allocation sequence was first defined in the aforementioned software by determining block sizes, allocation ratio, and stratification variables. Then, the final list was generated by coding the groups as 'A' and 'B' and kept in an encrypted file. None of the research team members had access to this file until participants were allocated to the groups. Allocation concealment was achieved by using opaque, sealed, and tamper-evident envelopes; each envelope had a serial number synchronized with the random sequence. Upon confirming the eligibility criteria, the person responsible for enrolling study participants opened the envelope corresponding to the individual's number and assigned the participant to the intervention or control group based on the contents inside the envelope. This process prevented the prediction of allocation and eliminated selection bias.

I will make a decision after completing the research and consulting with my supervisor.

After completing the research and after the article is published.

I will make a decision after completing the research and consulting with my supervisor.

I will make a decision after completing the research and consulting with my supervisor.

To all authors

Request to the authors

I will make a decision after completing the research and consulting with my supervisor.