For the random allocation of treatments to the three keloid lesions in each patient, a block randomization method with appropriate allocation concealment will be employed. For this purpose, all possible sequences (6 orders) for arranging the three studied treatments—namely PRP, 5-FU, and the combined method—will be prepared. These sequences will be randomly organized into blocks, and each will be placed in separate, sealed envelopes. In each patient, the three lesions will be identified and labeled according to their anatomical position (upper, middle, and lower). At the time of intervention, an envelope will be randomly opened for the patient, and the treatment sequence inside will determine which treatment is allocated to which lesion: the first element of the sequence to the upper lesion, the second to the middle lesion, and the third to the lower lesion. For example, if the selected sequence is "BCA," the upper lesion will receive 5-FU, the middle lesion will receive the combined therapy, and the lower lesion will receive PRP. This process, along with the use of sealed envelopes, ensures statistically balanced allocation and prevents any bias by concealing the sequences until the moment of allocation.