Evaluation of clinical and radiographic success of MTA، cold ceramic and 3-mix in the pulpotomy of mandibular second molars: randomized clinical trial

Determining the clinical and radiographic success of MTA (mineral trioxide aggregate) cold ceramic, and triple antibiotic paste in the pulpotomy of mandibular second molars

A controlled, double-blind, randomized, phase 2 clinical trial with parallel groups on 100 patients. The randomization function of Excel software was used for randomization.

In this study, 120 patients were randomly divided into 3 treatment groups with 40 patients in each group. 5-8-year-old children of both sex which visit the pediatric section of Isfahan Dental University participated in this study. following getting access to the pulp chamber and removing pulp tissue, 2 mm of MTA, Cold Ceramic, and 3-Mix will be put on the pulp canal. The teeth will be restored with glass ionomer and a stainless steel crown. The patients will be prescribed to come for recall in 3,6,12 months, assessing clinical and radiographical indexes of treated teeth.

Inclusion criteria: 1.5-8 year old children 2.having at least 1 primary second molar with the indication of pulpotomy 3.The teeth must not have pathological signs such as spontaneous pain, pathological luxation, internal resorption ,External resorption,PDL widening, inter-radicular radiolucency , Calcific metamorphosis. 4.The teeth must be score 1 of PAI index exclusion criteria : 1.systemic disease 2. physical and mental limitations 3. extra canal bleeding 4.sinus tract/swelling 5.pulp necrosis 6. allergic to the treatment 7. not cooperative in follow up sessions

MTA, Cold Ceramic, 3-Mix

Clinical success, defined by the absence of pain, swelling, abscess, sinus tract, and pathological mobility. Radiographic success, defined by the absence of furcation/periapical radiolucency and pathological root resorption.

Patients will be randomly allocated to one of the three treatment groups (MTA, Cold Ceramic, or 3Mix) using block randomization with a 1:1:1 allocation ratio. A computer-generated randomization sequence with fixed or variable block sizes will be prepared by an independent researcher not involved in patient recruitment or treatment. Allocation concealment will be ensured using sequentially numbered, opaque, sealed envelopes that will be opened only after the participant has been enrolled.

participants, healthcare providers (Physicians, nurses, physiotherapists, etc.) who care for participants during the trial, data collectors, and outcome assessors.