Inclusion criteria:
Age between 18 and 65 years
Chronic non-specific low back pain lasting at least 3 months
Presence of mechanical pain in the lumbar region without clinical evidence of specific causes of low back pain
Pain intensity of at least 4 on the Visual Analog Scale (VAS) at the time of study entry
Inadequate response to conservative treatments including medication, physiotherapy, exercise therapy, or activity modification during at least the past 6 weeks
Ability to cooperate and complete all clinical and functional assessments used in the study
Signing the written informed consent form to participate in the study
Exclusion criteria:
Presence of specific causes of low back pain including symptomatic disc herniation with radiculopathy, spinal canal stenosis, unstable spondylolisthesis, fracture, infection, tumor, or inflammatory spinal diseases
Presence of Red Flags including unexplained weight loss, fever, history of malignancy, progressive neurological deficit, or cauda equina syndrome
History of lumbar spine surgery
History of PRP, ozone, or other therapeutic injections in the lumbar region during the past six months
Neurological or musculoskeletal diseases affecting spinal and lower limb function
Active rheumatologic diseases or uncontrolled systemic diseases
Coagulation disorders or use of anticoagulant medications that cannot be temporarily discontinued
Presence of active local or systemic infection at the time of injection
Pregnancy or breastfeeding
Known sensitivity to blood products or impossibility of PRP preparation
Systemic corticosteroid use during the past three months
Inability to follow up regularly, lack of cooperation in assessments, or voluntary withdrawal from the study at any stage