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To find out the effect of Hyoscine - N - Butyl Bromide suppository on labor pain and process this study was down on 130 nulliparous term pregnant women who came to Ahwaz Sina hospital due to the beginning of spontaneous labor pain in 2009. The samples were divided randomly into groups of case (n=65) and control (n=65). A Hyoscine suppository (20 mg) was given to case group and a placebo suppository was given to control group in the beginning of active phase of labor rectally. Then the labor pain, cervical dilatation and effacement progress and active phase and second stage duration and delivery type were recorded.