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The purpose of this study was to evaluate acupuncture effect on Fibromyalgia in Iranian patients and compare with effect of Fluoxetine. This is a clinical trial study on the 30 outpatients with diagnosis of FMS referring clinics of Shiraz University of Medical Sciences. The patients were randomly assigned into acupuncture (study group) or Fluoxetine (control group). Patients in control group received Fluoxetine, 20 mg capsule every morning for 8 weeks. In acupuncture group, specific acupoints were needeled three times weekly for two weeks. Severity of symptoms measured through VAS and FIQ was measured at the baseline and 2, 4, and 8 weeks after the initiation of the interventions.