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This study assessed the efficacy of mouthwash with honey compared with hydrogen peroxide in oral lesions healing in Pemphigus patients. A randomized clinical trial was carried on 49 patients with oral pemphigus lesions. Patients randomly divided into experimental and control groups. Experimental group received honey mouthwash 12.5%, daily, half an hour after each meal. Control group received H2O2 mouthwash 1.5%, daily, half an hour after each meal. Patients were assessed for 10 days. Data were collected by questionnaire: Oral Mucositis Visual Assessment Guide of WHO, visual analog scale of pain intensity and time Diaries.