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This randomized trial evaluated the effect of Loratadine on the rate of readmission and the incidence of recurrent angina in patients with acute coronary syndrome in 200 patients diagnosed with acute coronary syndrome (Bravnvald class 2 and 3) admitted in the CCU ward of Ali Ibn Abi Talib Hospital (AS), Rafsanjan. The patients in the control group received Aspirin plus Heparin plus a beta-blocker. In the intervention group, Loratadine (oral tablet 10 mg daily for a month) was added to the medication of the control group. The frequency of recurrent angina and readmission were measured on a weekly basis and compared between groups.