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Study aim: Clinical evaluation of Delayed graft function (DGF) after kidney transplantation between the vitamin C arm and the placebo Design: A double-blind, randomized clinical trial with a control group and a placebo group design of 50 patients Settings and conduct: - This study will be conducted in a double blinded clinical trial with placebo in the kidney transplantation section of Imam Khomeini Hospital. - The study will begin after the receipt of the code of ethics and receive the approval of the Ethics Committee. - Patients undergoing kidney transplants for the first time will be considered for inclusion in the study and admission criteria. - In case of informed consent, patients will be introduced. - Patients are divided into two arms of treatment with vitamin C and placebo base on Permuted Block Randomization . Participants/Inclusion and exclusion criteria: Inclusion criteria: The first kidney transplantation Deceased donor Recipient age 14 years and older Patient informed consent to enter the study Non-inclusion criteria: Hemochromatosis Documented hyperoxaluria Multi organ transplantation History of Fauvism Preemptive kidney transplantation Exclusion Criteria: Patient's dissatisfaction with the continuation of research after entering the study Intervention groups: - Patients in the treatment arm receive 70 mg/kg vitamin C (at least 3 grams) at last hour before transplant surgery. The calculated dose is diluted in 250 ml of sodium chloride solution (0.45%) and infused over an hour before the transplant. In the placebo group, placebo (a saline solution of similar volume) is prescribed at that time. Main outcome variables: dialysis in the first week after transplantation
IRCTID: IRCT20100111003043N13
  1. Study of the changes in level of NGAL, biomarker of transplanted kidney function by application of N-acetyl cysteine in cadaveric renal transplant recipients
  2. Study of the effect of N-acetyl cysteine on the renal graft function biomarkers (IL18, NGAL)
  3. Comparing de novo versus delayed tacrolimus administration on allograft function in kidney transplant recipients: a randomized, open-label, clinical trial
  4. Assessment of the Efficacy of High-Dose Intravenous Vitamin C on Severity of Acute Graft Versus Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation: A Randomized, Triple-Blind, Placebo-Control Trial
  5. Evaluation of the effects of L-carnitine on liver function after liver transplantation
  6. Study of the effects of N-acetylcysteine on oxidative stress status of patients on maintenance-hemodialysis undergoing cadaveric kidney transplantation
  7. Investigating the effect of probiotic supplementation on progression of Carotid intima-media thickness after kidney transplantation, a triple blinded clinical trial study
  8. A servey of prophylactic effect of Mycophenolate Mofetil in delayed graft function and early outcome of living-kidney transplantation
  9. Comparison of efficacy and safety of extended-release versus immediate-release tacrolimus in renal transplant patients: a double-blind randomized controlled trial
  10. The effect of curcumin supplementation on nutritional status, glucose and lipid pattern, blood pressure, inflammatory status, oxidative stress, infection, and early graft function in patients after kidney transplantation
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