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A placebo controlled double-blind add-on study of Ginseng on the opioid withdrawal syndrome
We performed this randomized, double blind, placebo-controlled study to conclude a clinical data in human about the effects of Ginseng on opioid withdrawal symptoms. A total of 36 opioid dependent patients, all male, aged between 18 to 50 who met DSM-IV criteria for opioid dependence and started MMT protocol were randomly assigned to two groups of 18 to receive Ginseng (two 250 mg capsules daily) or placebo for first 15 days of detoxification. Patients were discharged from the study if they had positive urine tests indicating abuse of any drug and also if they missed more than one dose of Ginseng or a dose of methadone. Opioid withdrawal symptoms were measured by the COWS (clinical opioid withdrawal scale) on days 0, 1, 7, 10, 15. Also, the needed methadone dosage was counted everyday to be compared in two groups.
IRCTID: IRCT201009063106N4
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