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Medical sphincterotomy has gained popularity as a treatment for anal fissure. Ca channel blockers in topical forms may be appropriate treatment with low adverse effect. This study designed for comparing topical and oral nifedipine in treatment of chronic anal fissure. Methods: A prospective randomized controlled trial was conducted on 60 patients in topical nifedipine (0.5%) and 59 patients in 10 mg/TDS oral nifedipine. Patients were assessed on regular visit for pain score, blood pressure, pulse rate, healing of ulcer bed and side effects. The ultimate follow up period was 6m.