Aim: To determine the effect of massage on serum bilirubin levels in preterm neonates affected with hyperbilirubinemia. Infants admitted to Hashemi-Nejad hospital who have inclusion criteria, will be divided into two categories based on gestational age: 32-34 and 35-37 weeks. Then they will randomly be assigned to control and massage groups. Neonates of control group will receive routine ward care and neonates of treatment group will receive massage intervention. The intervention consists of massage 20 minutes, twice daily, for 4 days. Massage will be done one hour after the morning feeding and one hour after noon feeding. Massage starting on the face, mothers use two thumbs gently rubbing the preorbital and cheek regions; and then moving on the chest, two hands of performer from the lower margin of chest slide to opposite upper edge alternately; then to the abdomen, corresponding to the conformation of colon, the performer push a half circle gently, next is on the limbs, the performer use hand by hand with moderate pressure external side of the upper and lower limbs; and finally the back, the performer slide two hand from vertebra to two sides by neck to buttock.