A randomized controlled clinical trial study will be conducted with the aim of evaluation of the effect of acupressure of P6 and Le7 acu-points on nausea and vomiting, pain and vital signs of post-appendectomy patients. Post appendectomy patients are the participants in the study. A convenience sample of post appendectomy patients will be randomly allocated within the 3 groups. (45 patients in each group). Having an appendectomy surgery and willing to participate in the research are the main criteria for inclusion and occurring a complications during surgery or prolongation of the surgery (more than 2 hours) are the main criteria for excluding the patients from the study. The first group will receive acupressure on p6 acu-point. The second group will receive acupressure on le7 acu-point. The third group includes control group who will receive light pressure on shame points. Acupressure will be applied using an acuband in which a button applies pressure on the concerned acu-point. The intervention begins in the recovery room after full consciousness op the patients. At first, the severity of pain, existing and severity of nausea and vomiting, and the vital signs of the patients will be assessed and recorded in the checklist. Then the acuband will be placed on the concerned acu-point. The acuband will be maintained on the acu-points for seven hours. The severity of pain, existing and the severity of nausea and vomiting, and vital signs of the each patient will be assessed every hours. The severity of pain, severity of nausea and vomiting, and the quality of vital signs are the main outcome measures of the study. Data will be analyzed using t test, ANOVA, chi-square test, Fisher's exact test and kruskal wallis. For all tests, the maximum error of 0.05 will be considered.