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The aim of the present study was to determine the anti-inflammatory effects of fluoxetine on fatigue in patients with relapsing MS and also to survey the changes in sleep quality and depression
In a triple-blind, placebo-controlled exploratory study, 60 non-depressed patients with relapsing remitting MS were randomized to oral fluoxetine 20 mg or placebo daily for 24 weeks. fatigue, sleep quality and depression evaluation performed on weeks 1 and 24 by assessing FSS(Fatigue Severity Scale), PSQI(Pittsburgh Sleep Quality Index) and BDI(Beck Depression Inventory).Clinical activity of MS was also studied by assessing EDSS (Expanded Disability Status Scale)