Objectives: The aim of this research is evaluation of effectiveness of Mindfulness Based Stress Reduction (MBSR) on psychological symptoms, quality of sleep and quality of life inwomen with Multiple Sclerosis in Ahwaz city. Setting and conduct: Statistical population includes all MS patients that are member of MS association of Ahwaz. Forty women with MS are chosen using available sampling method and they are assigned to two groups randomly (Mindfulness Based Stress Reduction and the control group). All of the groups will receive usual medication too. The Mindfulness Based Stress Reduction group is participated in  therapy sessions. Participants of both groups will fill out Depression, Anxiety and Stress Scale (DASS), Petersburg Quality of Sleep (PSQG) and quality of life (SF-36) in three stages of pretest, post test and two month follow up. Major Inclusion and Exclusion criteria: inclusion criteria: being female;having at least 20 years and a maximum of 50years; having multiple sclerosis diagnosis by neurologist; having at least third-level education in guided school; agreement to participate in research according to informed consent and not receiving psychological treatment for at least a month before the study. Exclusion criteria:suffering from a diagnosed psychiatric illness; absence of more than three sessions and MS relapse. Intervention: the Mindfulness Based Stress Reduction group will receive eight weekly treatments. control group do not receive any psychotherapy. Main outcome measures: Depression, Anxiety and Stress, Quality of Sleep and quality of life