Study aim: Determining the effect of acupressure in several points on pain and physiological parameters of patients undergoing laparoscopic cholecystectomy surgery Design: In this clinical trial, 92 patients who are candidates for laparoscopic cholecystectomy are randomly selected. Participants are randomly based on a Random Digital Table divided into intervention and control group with parallel and double-blinded groups. Settings and conduct: The place of intervention is in the operating room of Al-Zahra hospitals in Isfahan, The research is double-blind, where the statistical analyst and the outcome evaluator do not know about the study groups. Participants/Inclusion and exclusion criteria: inclusion criteria: candidates for laparoscopic cholecystectomy surgery. Exclusion criteria: Drug and alcohol addiction; patient's intention to leave the intervention at any time. Intervention groups: In the intervention group, 30 minutes before the surgery, two acupressure steps will be performed on the patient with an interval of 20 minutes. In order to intervene, pressure points K1, H7, P6, LI4, LI11, SJ5 are pressed. Then, at the Post-Anesthesia Care Unit, and after ensuring the patient's consciousness, the intervention will be performed every 20 minutes up to 9 times on points K1, H7, P6, LI4, LI11, SJ5 respectively, and the participant in the control group will receive routine care. shoulder pain using a Visual Pain Scale and hemodynamic information including heart rate, systolic and diastolic blood pressure, breathing rate and heart rate is measured and recorded. Main outcome variables: patients' pain; blood pressure; heart rate; respiratory rate