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Evaluation the Effect of Silymarin on Serum Ferritin and Iron Level in Comparison with Placebo in β-thalassemia Patients undergoing Iron Chelation Therapy
A randomized, double-blind and crossover trial was performed on 70 beta thalassemia patients at the Thalassemia Research Center in Mazandaran University of Medical Sciences. The aim of this study was determination of silymarin effects on serum ferritin and iron levels in comparison with placebo in β-thalassemia patients undergoing iron chelation therapy. This study had been designed in three phases. During the first phase, patients were received silymarin tablet (420 mg - three times a day) or placebo tablet (three times a day) for 12-weeks. Phase 2 was a washout phase during 2-weeks. During phase 3, patients who randomly were assigned to receive silymarin were changed to receive placebo. Also, patients randomly were assigned to receive placebo during phase 1 were changed to receive silymarin. Serum iron, ferritin, and TIBC were measured immediately before and after each period. Change of treatment regimen was exclusion criteria during study.
IRCTID: IRCT2015101211819N2
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  2. Evaluation the Effect of Silymarin on Inflammatory Markers in Comparison with Placebo in β-thalassemia Patients undergoing Iron Chelation Therapy
  3. Combined therapy of silymarin and desferrioxamine in patients with b-thalassemia major: a randomized double-blind clinical trial
  4. The effect of oral quercetin supplement intake on oxidative markers , serum iron, liver enzymes and inflammatory indices in β-thalassemia major patients,a double-blind placebo-controlled clinical trial
  5. Comparison of Oral versus Injectable Iron Chelation Therapy in Reducing Serum Ferritin Levels in Patients with Transfusion Dependent Thalassemia
  6. Evaluation of the effect of amlodipine on oxidative stress markers and serum ferritin level in β-thalassemia patients undergoing iron chelation therapy: A randomized double-blind Cross-Over study
  7. Investigation the effectiveness and non effectiveness of oral administration of chicory extract on the decrease of ferritin serum in patients with thalassemia major and intermedia
  8. Investigation of the effect of oral amlodipine on cardiac and liver iron load and echocardiographic indices in patients with beta-thalassemia major
  9. A prospective single arm study to assess the efficacy and safety of deferasirox 20 mg/kg BID in transfusion dependent beta-thalassemia patients unresponsive to current treatment with doses > 35 mg/kg QD or with intolerance to single dose therapy
  10. Evaluation the efficacy of Livergol(Sylimarin extract) on liver function of thalassemia major and intermedia patients: A triple-blinded, randomized, placebo-controlled trial
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