Study aim: The aim of this study is to determine the effects of probiotic supplementation on levels of gene expression related with glycemic control, lipid and inflammatory factors in in patients with multiple sclerosis. Design: Parallel double-blind (both patients and researchers) randomized controlled clinical trial Settings and conduct: 40 patients with multiple sclerosis of eligible and referred to Beheshti Clinic affiliated to Kashan University of Medical Sciences, Kashan, Iran in the study will be selected Participants/Inclusion and exclusion criteria: Patients with multiple sclerosis and aged 18 to 55 years will be included in this study. The participants will be excluded from the study under following conditions: women who were pregnant or lactating during the past six months, taking probiotic or synbiotic products, menopaused women with irregular menstruation and unwillingness to utilize appropriate contraceptive tools. Intervention groups: Patients will be assigned to receive either probiotic (n=20) or placebo (n=20). Main outcome variables: Levels of gene expression related with glycemic control, lipid and inflammatory factors