Abstract Present research attributions mapped at the comparative scrutiny of Acceptance and Commitment Therapy (ACT) and Cognitive Behavior Therapy (CBT) impacts on psychological symptoms (tiredness, anxiety, stress and depression), resiliency and life quality amongst the Multiple Sclerosis (MS) patients. Present study counted as a clinical trials or treatment trials with pretest, post test and also 1.5 and 3 months two phase follow up that for sample selection population after the list preparation of an outpatient clinic of Baqiyatallah hospital visitors and call on them, 66 persons who were interested in therapy selected via convenience sampling method and randomly put in order as three groups (22 patients in ACT group, 22 patients in CBT group and 22 patients in control group). The input criteria such as; 20-40 years old-rage, ability of orderly participation in therapy sessions and conscious satisfaction of participation in research plan. And output criteria similar to; having serious signs of MS, affliction to or suffering from extreme or serious physical or mental disease and not intend to participation in therapy process. Not only in order to present study attributions; the first experimental group received 90 minutes Acceptance and Commitment Therapy per 8 sessions and the second one; received 90 minutes Cognitive Behavior Therapy per 10 sessions, but also there was no intervention about control group. Variables of primary consequence; tiredness, anxiety, stress and depression and Variables of secondary or afterthought consequence; resiliency and life quality.