This study is a randomized control trial to determine the effects of Spiritual-Religious care on depression intensity in women with multiple sclerosis. All of the multiple sclerosis female patients, who were referred to Iran MS associations, were our statistical research community. Of them, 70 patients were selected based on inclusion criteria included: being Muslim, not participated in previous training programs about Spiritual-Religious care and Spiritual counseling in Last three months, Patients suffering from moderate level of disease according to disability intensity and symptoms and they were randomly divided into two experimental and control groups using table of random numbers. Religious spiritual care sessions were held according to Richard Burgin pattern for the intervention group in the form of group education, in seven sessions. Depression intensity was the main outcome and therefore patients filled oud Beck Depression Inventory before and after the intervention.