Background: Multiple sclerosis is an autoimmune disease that create Family disruption , economic hardship and psychological distress . Although there is no cure for this disease, but psychotherapy or use complementary therapies to reduce symptoms of the disease have been effective. The aim of this study is to assess the effectiveness of cognitive group hypnotherapy on psychological well-being in patients with multiple sclerosis is Yasuj. Methods: This study is a clinical trial. A total of 30 patients with multiple sclerosis who have been admitted to the Mofateh clinic in Yasuj selected and randomly assigned into experimental and control group. For experimental group 8 sessions for one and a half hours of weekly cognitive hypnotherapy will be treated but control group received no intervention. This Reef psychological well-being questionnaire (Short Form 21-item) will be used to assess psychological well-being. Before and after the intervention, both groups will fill the questionnaire. The gathered data will be analyzed using SPSS 23.