Study aim: The general goal of determining the effect of acupressure on nausea and vomiting and anxiety caused by chemotherapy in school-age children with Acute lymphoblastic leukemia Design: A clinical trial with a control group, one blind, randomized, sample size of 60 children with Acute lymphoblastic leukemia Settings and conduct: The place of the study in the Amir Kabir Hospital of Arak. 60 Children with acute lumphocytic leukemia are randomly divided into two groups of intervention and control. Acupressure intervention at pericardium (p6) to reduce nausea and vomiting. The first day of chemotherapy 1 hour after the end of the first chemotherapy (3 times each time for 1 minute). Thirty minutes to one hour after the end of each pericardium interference, a subsequent intervention of acupressure at the Shen men point to reduce anxiety (3 times per minute for 1 minute). In the control group, on the first day of chemotherapy and one hour after the end of the first-order chemotherapy, acupressure intervention was performed at the false point of S13. (3 times each time for 1 minute). Participants/Inclusion and exclusion criteria: Sample specification and entry criteria: Knowledge of time and place; Knowledge and history of using acupressure for any purpose; There is no specific problem in the place and place of acupressure (no scar, ecchymosis, mass or pain); Not suffering from certain chronic diseases (hemophilia, diabetes ...); Literacy, reading and writing, and the ability to complete a questionnaire (by the child or with the help of parents); do not have platelet less than 50,000 (due to the possibility of pressure-related bleeding); In the past six months, there has been no anxious event, such as the death of a first-degree relative, divorce, or father-in-work unemployment; Parents are not from the medical group. Exit criteria: Possible death; Possible exemption from continuing participation in a potential; transfer study to a health facility in another city. Intervention groups: Acupressure intervention at pericardium (p6) to reduce nausea and vomiting. The first day of chemotherapy 1 hour after the end of the first chemotherapy (3 times each time for 1 minute). Thirty minutes to one hour after the end of each pericardium interference, a subsequent intervention of acupressure at the Shen men point to reduce anxiety (3 times per minute for 1 minute). In the control group, on the first day of chemotherapy and one hour after the end of the first-order chemotherapy, acupressure intervention was performed at the false point of S13. (3 times each time for 1 minute). Main outcome variables: Expected Outcome REDUCE Nausea and Vomiting and Anxiety Induce by Chemotherapy in Children with Acute Lymphoblastic Leukemia