Study aim: Comparison the biomechanical gait efficacy ( kinetic, kinematic and spatiotemporal) newly designed Ankle Foot Orthosis on Multiple sclerosos Design: Clinical trial, without blinding, phase 2 with 12 patients Settings and conduct: At the start of examination, fifteen retro reflexive markers were attached based on modified Helen Hyes marker markers placed bilaterally on the anterior and posterior superior iliac spine, the posterior sacrum, medial and lateral femoral condyles. heel, lateral malleolus, top of the second metatarsal phalangeal joint (toe). Then, all stage of the examination was explained to the participants and wants them to walk with self selected walking speed in 10 meters at walkway in two conditions of with shoes only /with the new orthosis and shoes. The patients had 10 min of rest between each trial. Each trial was repeated five times. Participants/Inclusion and exclusion criteria: Subjects diagnosed with MS (6 months), the extended disability scale EDSS of 4 to 6, unilateral drop foot, endurance to ambulate at least 30 feet continuously with minimal assist or less without the use of an AFO, the maximum spasticity of grade II (Ashworth scale) with plantar flexor muscles, and history of using passive AFO were entered in this study. Intervention groups: Newly designed Ankle Foot Orthosis Main outcome variables: Spatiotemporal parameters, Kinematic parametrs, kinetic parameters