Study aim: Evaluation and comparison of the effect of prednisolone + cimetidine and prednisolone + colchicine in the treatment of fever and frequency of attacks in PFAPA syndrome Design: two intervention groups, parallel, triple blind, randomized"The response to treatment is evaluated by comparing the number of fever attacks and the duration of fever periods. Data analysis was performed by SPSS" Settings and conduct: Children's Medical Center & Vali Asr Hospital Participants/Inclusion and exclusion criteria: Inclusion criteria 1. Age of onset of symptoms from 1 year to 10 years of age 2. Absence of inflammatory or other rheumatic disease, simultaneously 3. No concomitant disease in which there are contraindications (prednisolone, cimetidine, colchicine). Exclusion criteria: 1. Causing any other rheumatic disease during treatment. 2. Changing the diagnosis of the patient during treatment based on laboratory or clinical symptoms. 3. Lack of proper follow-up and unwillingness to attend the study. 4. Use other treatments that affect the course of the disease, such as specific diets and herbal remedies. Intervention groups: The study was performed on 80 children with PFAPA syndrome referred to the Pediatric Rheumatology Clinic between October 2019 and June 2020.Patients will be randomly divided into two groups of prednisolone plus cimetidine and prednisolone plus colchicine. The first group will be treated with prednisolone during fever and in addition to prednisolone, cimetidine will be given daily. In the second group, prednisolone is given for fever and will be given daily. The duration of the fever period and the number of fever attacks before and after the treatment are recorded in a questionnaire.Two visits will take over a period of 3 months Main outcome variables: Duration of fever "Age" Number of fever attacks "Diagnosis of PFAPA" treatment regimen