Study aim: Comparison of the effect of sublingual mesoprostol, rectal and venous oxytocin on cesarean uterine bleeding Design: Clinical trial with control group, with parallel groups, single blind, simple random,Randomization through block randomization, on 180 patients. Settings and conduct: This study will be performed on a single blind in the operating room of Shahid Sayad Shirazi Hospital in Gorgan on pregnant mothers who are candidates for cesarean section. The sampling method is random and through block randomization, the samples are divided into 3 groups of 60 people. We divide: (groups A, B and C) 1) Group A: Sublingual mesoprostol tablets + intravenous oxytocin 2) Group B: Rectal misoprostol tablets + intravenous oxytocin 3) Group C = or control : Intravenous oxytocin Participants/Inclusion and exclusion criteria: Inclusion criteria: Patients between the ages of 18 and 40, cesarean section candidate, gestational age between 37 and 40 weeks, Spinal anesthesia candidate, patient consent, single pregnancy and low transverse uterine incision. Exclusion criteria: history of PPH (postpartum hemorrhage), placenta proia and acarta, liver or kidney disease, eclampsia and preeclampsia, epilepsy, height below 155 cm, obesity (BMI> 40) ( BMI = Body mass index), infant weight over 4 kg, polyhydramnios (increase) Amniotic fluid), patients receiving anticoagulants, patients with heart and lung problems and underlying diseases such as diabetes, hypertension (hypertension above 140/90 mm Hg), chronic anemia, coagulation disorders and immunodeficiency. Intervention groups: Samples will be divided into three groups, A, B and C. 1) Group A: Sublingual mesoprostol tablets + intravenous oxytocin 2) Group B: Rectal misoprostol tablets + intravenous oxytocin 3) Group C = or control : Intravenous oxytocin Main outcome variables: Bleeding during cesarean section