Study aim: Determining and comparison of the effect of aromatherapy and edible rose essential oil on saliva cortisol level and quality of life of chronic renal failure patients undergoing hemodialysis. Design: Clinical trial without control group, with parallel groups, non-blind, randomized groups, 72 patients. Settings and conduct: The studied population is hemodialysis patients referred to Shahid Beheshti and Shahid Jalil hospitals in Yasouj. After the approval of the research proposal by the Research Ethics Committee of Yasouj University of Medical Sciences, at the beginning of the study, questionnaires of demographic characteristics and short form of kidney disease quality of life will be completed and a saliva sample will be taken early in the morning. One month later, the patient's saliva will be collected again using ELISA kits to measure the salivary cortisol level and the short-form kidney disease quality of life questionnaire will be completed. Participants/Inclusion and exclusion criteria: Inclusion criteria: 1. At least three months have passed since hemodialysis. 2. Doing dialysis at least 2 to 3 times a week Exclusion criteria: 1. Allergy to Rosa damascene and patient reaction to it 2. Taking anti-anxiety and anti-depressant drugs Intervention groups: The two intervention groups will be aromatherapy and oral intake. In aroma therapy group, when the patient is connected to the dialysis machine, a piece of cloth soaked in 3 drops of rose essence with a concentration of 2% is attached to the patient's collar and the patient will be asked to breathe normally. This work will be done 3 times a day and each time for 5 minutes for 4 weeks. In oral intake group when the patient is connected to the dialysis machine, 15 drops of rose extract will be poured into some water and every 8 hours given to him/her (3 doses in day). Main outcome variables: Salivary cortisol levels and Quality of life