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Study aim: evaluate the efficacy (rTMS) as an adjunct therapy in combination with medication and localization in Iranian patients. Design: Two arm parallel group randomized trial with blinded postoperative care and outcome assessment. Random allocation will be used in this trial based on balance block randomization and by 4:1 blocks. To do study with concealment, table of block will be used by one of researchers, other than interviewer and who assess patients in follow-up visits, to write number of each participants on box of additional drugs. Therefore, all of patients, interviewer and who assess patients in follow- up visits will be unaware if each number belongs to which groups. Settings and conduct: Patients with a history of OCD who referred to the 22-Bahman Hospital's Psychiatric Clinic were interviewed by a psychiatrist who had DSM5 diagnostic criteria for obsessive-compulsive disorder Participants/Inclusion and exclusion criteria: age 18-60 years History of moderate to severe persistent OCD The subjects did not score above 17 according to the Beck Depression questionaaire Exclusion criteria association with other psychiatric illnesses, history of epilepsy history of drug abuse history of neurosurgery complications having any type of metal implant Intervention groups: Group A was treated with(rTMS) for 5 days (5,200 pulses / day) for 3 weeks at the same time as taking the drug While patients in group "B" were only treated with standard medication and sham was used for them so that the device was placed on their scalp without magnetic stimulation Main outcome variables: Severity of obsessive-compulsive disorder
IRCTID: IRCT20200728048240N1
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  5. Comprative effectiveness of transcranial Direct Current Stimulation (tDCS) in both PreSMA and LOF inhibition and comparing them with placebo in reducing symptoms in nonresponsive OCD patients
  6. Comparison of treatment with Repetitive Trans cranial Magnetic Stimulation with medication, with medication alone in obsessive-compulsive disordered resistance to medication
  7. L-Theanine combination therapy with Fluvoxamine in moderate to severe obsessive-compulsive disorder: A placebo-controlled, double-blind, randomized trial
  8. Reboxetine combination therapy with Fluoxetine in the treatment of moderate to severe obsessive-compulsive disorder: A randomized double blind and placebo controlled clinical trial
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