Study aim: Determination of effect of herbal nasal spray based on Oregano on Migraine headache Design: Two arm parallel group randomized control clinical trial, double-blind, phase 3. 70 patients, Block Random Allocation. Settings and conduct: Among patients who come to Persian Medicine clinic of Tehran University, the patients who have migraine headache based on IHS criteria; are informed about the survey and if willing they are clearly informed about the procedure. After informed consent they are randomly entered in drug and placebo groups. A note book is designed for them to enter their headache information in that: the time and duration of headache, analgesic name and number used while headache, probable side effects. Finishing the survey the recorded information are investigated and beside Health-related quality of life tests are calculated as final results. Participants/Inclusion and exclusion criteria: Entrance criteria: 1. Migraine headache based on IHS 2. 2 to 8 attacks per month with headache days less than 15 per month 3. Onset of headaches no sooner than a year ago 4. No warm brain temperament 5. age between 18 and 65 with onset of headaches sooner than 50 years old Exclusion criteria: 1. Secondary headache 2. Antipsychotic and antidepressant drug for reasons other than migraine in last 3 months 3. Alcohol or drug abuse 4. Drug sensitivity to the drug in experiment ingredients 5. Fertile women with no contraception 6. Pregnancy and breast feeding 7. using a drug which could affect migraine headache during last week 8. drug overuse based on IHS criteria 9. Severe physical or psychological disease Intervention groups: Drug and placebo spray Main outcome variables: Number of Migraine headache attacks