Study aim: The aim of this study is to evaluate the topical application of royal jelly on wound healing process of extracted teeth of maxilla and mandible. Design: Clinical trial with parallel groups, triple blinded and randomized. For randomization Random allocation software will be used. Groups are formed as control of maxilla and mandible, study of maxilla and mandible. Settings and conduct: The study will be held at oral and maxillofacial surgery section of isfahan university of medical sciences. After tooth extraction and rinsing the socket with sterile normal saline, in control groups gelatamp smeared with sterile normal saline will be applied on the fresh tooth socket. In study groups gelatamp smeared with royal jelly which is freeze dried and diluted to 5% in sterile normal saline will be applied on the fresh tooth socket. In all patients study variables will be evaluated and recorded in study and control groups in two periods (after tooth extraction and 1 week later). Patients, dentist recording variables and statistics analyzer won't be aware of patient's groups. Participants/Inclusion and exclusion criteria: Patients referred for extraction of not impacted molar teeth in maxilla or mandible, being at least 18 years old and healthy enter the study. In case of pregnancy, using medication or mouthwash, need of antibiotic prophylaxis, allergy to honey, addiction or regional infection patients won't enter the study. Intervention groups: In control groups gelatamp smeared with sterile normal saline will be applied on the fresh tooth socket. In study groups gelatamp smeard with royal jelly which is freeze dried and diluted to 5% in sterile normal saline will be applied on the fresh tooth socket. Main outcome variables: The variables of the study include the size of the wound, bleeding after touching, the appearance of pus, the appearance of granulation tissue, the color of the tissue and pain.