Study aim: Determining the equivalence of acceptance and commitment-based therapy focusing on compassion and yoga exercises on self-management, difficulty in emotion regulation, pain acceptance and pain catastrophizing in multiple sclerosis patients. Design: A clinical trial with a control group and two other groups, a blind strain, by available sampling method, on 45 patients. Settings and conduct: This study is conducted on MS patients, and the setting for the group receiving acceptance and commitment therapy with a focus on compassion is the MS Association and the group doing yoga exercises is a yoga club. Participants/Inclusion and exclusion criteria: Entry conditions: definitive diagnosis based on neurological examinations and magnetic resonance imaging by a specialist doctor; not suffering from other neurological and chronic diseases at the same time; Not suffering from psychological disorders. Non-entry conditions: suffering from other neurological and chronic diseases; suffering from severe psychological disorders at the same time; Taking psychiatric and psychoactive drugs Intervention groups: One group receives Compassion-Focused Acceptance and Commitment Therapy, which is a third-wave therapy that combines an Acceptance and Commitment Therapy approach with a Compassion-Focused Therapy approach. A group of yoga exercises that combine asana (movement), pranayama (breath control), relaxing meditation. The control group receives no treatment approach.. Main outcome variables: Self management ; Difficulty in regulating emotions; Acceptance of pain; Pain catastrophizing